However, we have not observed clear rescue of the Zswim8−/− perinatal lethality, lung sacculation, or embryonic growth phenotypes (scoring for either cyanosis and survival rates at birth or lung histology and embryonic weights at E18.5) in animals with deletions designed to reduce the levels of key ZSWIM8-sensitive miRNAs, including miR-17∼92Δ17,18,92/+, miR-106b∼25−/−, maternal Mirg–, and miR-322∼351−/− (Ventura et al. 2008; Llobet-Navas et al. 2014; Han et al. 2015; Marty et al. 2016). This evidence concerns the gene ZSWIM8 and Abnormality of the skin.