Meanwhile, DPP-4 inhibitors are sometimes able to reduce albuminuria in T2DM patients with renal dysfunction (Groop et al., 2013; Udell et al., 2015) and attenuated kidney injury in induced diabetic rats (Liu et al., 2012; Sharkovska et al., 2014). This evidence concerns the gene DPP4 and Abnormal renal physiology.