Interestingly, when we co-stain for AT8, a marker commonly used to study hyperphosphorylated tau in neurodegenerative disease [31], we reveal that these areas of axon and myelin loss (i.e. NF200- and MBP- signal) correspond with abnormally high levels of AT8+ phosphorylated tau. This evidence concerns the gene MBP and neurodegenerative disease.