18F-Labeled [60]fullerene-based molecularsphericalnucleic acids (MSNAs), consisting of a human epidermal growth factorreceptor 2 (HER2) mRNA antisense oligonucleotide sequence with a nativephosphodiester and phosphorothioate backbone, were synthesized, site-specificallylabeled with a positron emitting fluorine-18 and intravenously administratedvia tail vein to HER2 expressing HCC1954 tumor-bearing mice. The gene discussed is ERBB2; the disease is neoplasm.