However, for some chemicals,the oxidative stress response can also be triggered by direct bindingof the test chemicals to Keap-1, which has been identified as a molecularinitiating event for skin sensitization,79 but direct reactions with Keap-1 and acrylamides have not yet beendemonstrated.81 The results of this studycan be used to deduce the probable behavior of the chemicals in humansand their potential effects on human health. The gene discussed is KEAP1; the disease is skin sensitization.