Regarding individual genes, interestingly, for two VAGs with experimentally validated role in urinary tract infection, pap genes [36] and fim genes [37], we found a higher level of significance in B2 strains with urinary portal of entry than in all B2 strains (pap) or in all strains (fimD-H) (S4 Table). Here, ZMYM2 is linked to urinary tract infection.