Among the selected SFs, we identified five SFs that had significantly increased expression in the tumor samples compared to normal tissues (SRSF2 (P < 0.01), U2AF2 (P < 0.01), HNRNPA2B1 (P < 0.01), SRPK1 (P < 0.01), and HNRNPA1 (P < 0.01), Fig 4B–4F). The gene discussed is U2AF2; the disease is neoplasm.