RPS6 and Insulin resistance: Additionally, activated AKT can lead to an increase in mammalian target of rapamycin complex (mTOR), further facilitating the phosphorylation of p70 ribosomal S6 kinase 1 (S6K1) and activation of the ribosomal protein S6 (rpS6), which promotes protein synthesis and plays an important role in insulin resistance [19, 20].