SCN3A and spinal cord injury: It was shown that Nav1.3 overexpression occurs in rat DRG neurons after peripheral axotomy (Dib-Hajj et al., 1996) or spinal cord injury (SCI; Hains et al., 2003; Lampert et al., 2006), leading to hyperexcitability of DRG nociceptive neurons and pain-related behavior due to rapidly repriming TTX-sensitive currents.