IGFBP3 and Creutzfeldt Jacob disease: Also PRNP variants rs1799990, rs6107516 and rs6116492, which are associated with Creutzfeldt-Jakob disease and share some symptoms with ALS, and IGFBP3 variants rs10597497, rs2965072 and rs1542820, which are associated with brain volume and morphology changes, are potentially relevant to ALS [82].