High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6–R (DHL/THL) are defined by their genetic background and were recognized as highly aggressive B-cell lymphomas that can occur de novo or as transformations from prior lymphomas, most often FL or DLBCL, nos [3–7]. Here, MYC is linked to B-cell non-Hodgkin lymphoma.