From a practical standpoint, HGBCL, nos are a diagnosis of exclusion in which a lymphoma with intermediate or blastoid cytomorphology and starry sky pattern triggers a “high grade” workup to exclude BL, HG/LBCL-11q, and HGBCL with MYC- and BCL2- and/or BCL6-rearrangement. The gene discussed is BCL6; the disease is lymphoma.