CD274 and diffuse large B-cell lymphoma: Cytogenetic studies showed a mild amplification of REL, but no evidence of PDL1 gain/amplification or rearrangements of MYC, BCL2, or BCL6, and sequencing studies demonstrated mutations in EZH2 and EP300, a genetic profile more in keeping with the GCB or EZB subtype of DLBCL [28].