While the RT-MLPA assay [4], which uses three genes to identify PMBL (FCER2/CD23, TNFRSF8/CD30, and MAL), showed a PMBL GE signature, the Lymph3Cx assay [8], which uses 30 genes to discriminate PMBL from DLBCL, showed an “unclear” GE signature. Here, TNFRSF8 is linked to diffuse large B-cell lymphoma.