Many studies in CRC cells and associated fibroblasts and in experimental animals have shown a large series of VDR-mediated VD anti-CRC effects (Carlberg and Muñoz, 2022a; Carlberg and Velleuer, 2022b; Feldman et al., 2014; Fernández-Barral et al., 2020; Ferrer-Mayorga et al., 2019) In support, germline deletion of Vdr in mice with constitutively active Wnt/β-catenin signalling, as a main driver of CRC, results in increased intestinal tumour load (Larriba et al., 2011; Zheng et al., 2012). The gene discussed is VDR; the disease is intestinal neoplasm.