CGAS and neoplasm: Mn2+ could decompose the endogenous H2O2 into O2 to relieve hypoxia and enhance thesensitivity of cGAS, activating the cGAS-STING signaling pathway.In addition, this strategy allowed the reprogramming of the immuneTME, inducing macrophage polarization and dendritic cell maturationvia antigen cross-presentation, thereby increasing the immune system’sability to combat the tumor effectively.