TRPV4 and acute respiratory distress syndrome: In conclusion, the main findings of this study were as follows: (1) Ferroptosis was increased in LPS-induced ALI; (2) TRPV4 expression and Ca2+ influx were up-regulated in ALI stimulated by LPS; and (3) inhibition of TRPV4 improved ferroptosis in ALI stimulated by LPS in vivo or vitro.