RAF1 and Noonan syndrome: Table 2 summarizes the genes and domains involved in RASopathies. KRAS (2.8%) and NRAS (0.8%) have the lowest incidence among all reported cases of Noonan syndrome caused by the RAS subfamily of genes involved in the RAS/MAPK pathway, in contrast with the RIT1 gene in the same family. Similarly, BRAF constitutes 2.3% among RAF family members compared to the more prevalent RAF1. Table 1 emphasizes the genes involved in different RASopathies and their normal function, mutation type, mutation location, and cardiac implications.