CD8A and neoplasm: Compared with the low-risk group, the high-risk group showed a significantly reduced number of anti-tumor-infiltrating immune cells, such as CD8+ T cells and Tregs but an increased number of M2 macrophages, which are immune cells promoting tumor proliferation and metastasis (Togashi et al., 2019; Xia et al., 2020; Reina-Campos et al., 2021).