After infecting -T/-NK cells, viral oncoproteins, such as LMP-1, stimulate the constitutive activation of intracellular signaling pathways AKT, JAK/STAT (STAT3, JAK3, and STAT5B), MAPK, and nuclear factor kappa B (NF-κB), inhibiting apoptosis, promoting cell proliferation, and modulating the immune response, consequently regulating the interactions between the neoplastic compartment and the non-tumor immune microenvironment (69). This evidence concerns the gene JAK3 and neoplasm.