Although recurrent somatic mutations (single-nucleotide variant (SNV)) have been reported at high frequency in ENKTCL, particularly those involving the DDX3X RNA helicase, TP53, JAK/STAT pathway genes, and epigenetic modifiers, its tumor mutational burden (TMB) is usually lower than observed in other NHLs, such as the diffuse large B-cell lymphoma (DLBCL). This evidence concerns the gene TP53 and diffuse large B-cell lymphoma.