After adjusting for age, sex, drinking, CEA, ALP, sTNFR-II, and endotoxin, partial correlation analyses showed that smoking was positively correlated with Eggerthella in the type II CRC subgroup and with Family XIII UCG-001 in the type II adenoma subgroup (Supplementary file Tables 8 and 9). This evidence concerns the gene CEACAM5 and adenoma.