In addition, gene K08738 (KEGG) encoding cytochrome C (CYC), which was found to participate in the p53 signaling pathway, was found to be significantly enriched in both the type II CRC [FDR adjusted p<0.001, Log2(FC)=1.37] and type II adenoma [FDR adjusted p=0.005, Log2(FC)=1.11] subgroups (Supplementary file Table 15). Here, CYCS is linked to adenoma.