Bioinformatics analysis verified that <i>UBR4</i> was low expressed in cryptorchidism patients, which further supported the important role of <i>UBR4</i> in male fertility.<h4>Discussion</h4>Overall, our findings suggest that <i>UBR4</i> deficiency could promote male infertility and may be involved in the protein modification of <i>UBR4</i> by upregulating <i>Sfp65A</i> and <i>CG11598</i>, whereas downregulating Pelota protein expression. The gene discussed is UBR4; the disease is cryptorchidism.