FMR1 and ovarian dysfunction: a. X chromosome short arm (Xp) deletion in POI patients often involves Xp11.2~p22.1 proximal to the short arm, and most of the equilibrium translocation break points are distributed in the POF2 (Xq13~q21) region, and the deletion and rupture of the POF1 (Xq26~q28) and POF2 (Xq13~q21) regions will lead to ovarian dysfunction.