The morphology and grade of the tumor, tumor size, lymph node metastases status, and progesterone receptor (PR), estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) expression profiles are considered together while evaluating the patients’ condition (Fragomeni, Sciallis, and Jeruss 2018; Goldhirsch et al., 2013). This evidence concerns the gene ESR1 and neoplasm.