The effect of these inhibitors on the release of other prostaglandins and thromboxane in supernatants was similar to that of genetic depletion of ptgs2 and ptges in murine BrafV600E melanoma cells (Fig. 1E–H); only celecoxib decreased TxB2 production (Supplementary Fig. S11A), whereas PGD2, PGF2α, and 6-keto PGF1α production were suppressed by celecoxib and increased by CAY10678 (Supplementary Fig. S11B–S11D). The gene discussed is PTGES; the disease is melanoma.