HAVCR2 and neoplasm: In contrast, the number of tumor-infiltrating Tim3+ exhausted CD8a+ T cells was significantly lower in mice treated with single-agent CAY10678 or CAY10678 plus αPD-1 compared with any other treatments (Fig. 6D), and the percentage of Tim3+ exhausted CD8a+ T cells in total CD8a+ T cells was significantly suppressed by CAY10678-based treatments compared with celecoxib-based treatments although αPD-1 monotherapy also strongly suppressed the frequency (Supplementary Fig. S12C).