To elucidate the role of the Nrf2/HO-1 pathway in the in vitro PD model, Nrf2 was silenced, and our results revealed that Bax expression was encouraged, Bcl-2 expression was discouraged, level of SOD was improved, and levels of ROS, LDH, and MDA were inhibited. The gene discussed is HMOX1; the disease is Parkinson disease.