MCM7 inhibition led to a decrease in the esophagus (Qiu et al., 2017) and hepatocellular carcinomas (Qu et al., 2017) viability, colony-forming ability, and migration capacity due to reducing phosphorylation of AKT1 and mTOR proteins with decreasing CDK1, CCNE1, and CCNE2 expression levels (Qiu et al., 2017). This evidence concerns the gene CCNE2 and hepatocellular carcinoma.