Phosphoglucomutase 1 (PGM1) is crucial in modulating insulin secretion (Galcheva et al., 2018) and implicated in congenital hyperinsulinemia (Gϋemes et al., 2020), but the mechanism and role of PGM1 in T2DM have not been investigated. Here, PGM1 is linked to Hyperinsulinemia.