Among these genes, CRK, CRKL, EGF, EGFR, ERBB2, GRB2, GSK3B, HRAS, JUN, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, PAK1, PAK2, PAK7, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKCA, PRKCB, PRKCG, PTK2, RAF1, RHOA, RPS6KB1, SHC1, SHC3, SOS1, SOS2, SRC, THBS1 genes can be potential T2D causing genes. This evidence concerns the gene SHC3 and type 2 diabetes mellitus.