Supplementary Figure 1C exhibits the upregulation of HK2, but not endogenous HK2, protein after infection with Ad-HK2FL and Ad-HK2ΔN. On the other hand, confocal immunofluorescent studies (Supplementary Figure 1D) indicate that there is a significant binding of HK2 to the mitochondria when incubated with Ad-HK2FL adenovirus rather than Ad-HK2ΔN adenovirus. Figures 2A-D demonstrate the potential role of HK2FL in aggressive behavior of RA FLS by looking at invasion (Figures 2A, B) and migration (Figures 2C, D). The gene discussed is HK2; the disease is infection.