To determine the effect in arthritis of dissociation of HK2 from mitochondria, MJ was injected either same day as K/BxN serum (d0) (Figures 7A-C) or 5 days (Figures 7D, E) in the K/BxN arthritis model, using doses of 25 and 100 mg/kg. The gene discussed is HK2; the disease is arthritic joint disease.