As the monoclonal antibody MECA79 recognizes HEV-expressing peripheral node addressin (PNAd) proteins, some investigators have used MECA79 NP to recognize HEVs in PDAC tissues to deliver the chemotherapeutic drug paclitaxel to tumor tissues, resulting in a significant reduction in tumor size and abnormal intratumor angiogenesis. The gene discussed is NTAN1; the disease is neoplasm.