In ovarian cancer, promotion of Tfh cell differentiation induces larger TLS formation as well as B-cell recruitment, along with increased FAS and GL7 expression (46); in non-small cell lung cancer (NSCLC), the interaction between Tfh cells and B cells via the CXCL13-CXCR5 axis induces smaller TLS formation within tumors (47). Here, CXCR5 is linked to non-small cell lung carcinoma.