Similarly, in vitro treatment of recombinant leptin to pancreatic cancer cells caused a significant increase in p-Akt in Panc-02 and Panc-1 pancreatic cancer cells, but MiaPaCa-2 cells did not activate p-Akt in response to leptin regarded to the short and long forms of the leptin receptor in cells (Mendonsa et al., 2015). This evidence concerns the gene LEPR and pancreatic neoplasm.