LEP and familial pancreatic carcinoma: Similarly, in vitro treatment of recombinant leptin to pancreatic cancer cells caused a significant increase in p-Akt in Panc-02 and Panc-1 pancreatic cancer cells, but MiaPaCa-2 cells did not activate p-Akt in response to leptin regarded to the short and long forms of the leptin receptor in cells (Mendonsa et al., 2015).