Even though males account for 80% of persons with SCI and near 97% of veterans with SCI are males,1,46 it is necessary to conduct additional studies using female ApoE4 mice expressing normal or reduced levels of synj1 to test for any possible sex differences, given that sex has been reported to be an important biological variable in AD pathogenesis.47 Of note, our previous work did not show any sex differences between ApoE4 mice after incomplete SCI,22 leading us to speculate that any sex discordance that may be observed is unlikely to be large. Here, APOE is linked to Alzheimer disease.