PTEN and glioblastoma: This analysis corroborated the finding that age and PTEN loss and/or mutation were independent prognostic markers of OS in patients with TERTp-wild-type GBM (HR: 2.69 [1.19–6.10], P = .018; and HR: 0.29 [0.11–0.76], P = .001, respectively; Table 3).