Interestingly, evidence points toward an interplay between PTEN and TP53 in which they regulate each other at the transcriptional and protein levels.42,43 Our most striking finding was that PTEN, TP53, CDKN2A/B, and PDGFRA are important driver genes in the molecular classification of IDH- and TERTp-wild-type GBM. Here, PTEN is linked to glioblastoma.