The main tumors related to TFE3 gene fusion include renal cell carcinoma [28, 29], alveolar soft-part sarcoma (ASPS) [30, 31], epithelioid hemangioendothelioma [32], rare ossifying fibromyxoid tumors [33], malignant chondroid syringoma [34], and perivascular epithelioid cell tumors [35]. Here, TFE3 is linked to hereditary clear cell renal cell carcinoma.