Among the CLL cell survival related signaling pathways that are well studied, Phosphatidylinositol-3-kinase/ Protein kinase B (PKB), also known as Akt (PI3K/AKT), Nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), Nrf2, Mitogen-activated protein kinase/ extracellular signal-regulated kinase (MAPK/ERK), WNT, and Neurogenic locus notch homolog protein 1 (NOTCH1) can be mentioned [10, 11]. The gene discussed is NFKB1; the disease is B-cell chronic lymphocytic leukemia.