NFE2L2 and large cell neuroendocrine carcinoma: The human protein NF-E2-related factor 2 (Nrf2) is another overexpressed element seen in various hematologic malignancies such as Chronic myeloid leukemia (CML), Acute myeloid leukemia (AML), Acute promyelocytic leukaemia (APML), Acute promyelocytic leukemia (APL), CLL, and Acute lymphoblastic leukemia (ALL) which is also seen in many solid malignancies like pulmonary, head and neck masses, adenocarcinoma, and large cell neuroendocrine carcinoma [14–16].