Our novel NPs containing CP as the cytotoxic agent were capable of reducing cell proliferation and apoptosis induction in malignant CLL cells, supported by the alterations in Bcl-2-associated X protein (Bax)(apoptotic) and Bcl-2 (anti-apoptotic) factors in favor of increased apoptosis. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.