reported a drastic increase in apoptosis of TRAMP-C1 cell line and prostatic malignant cells of Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP mice) after treatment with 3,3'-diindolylmethane (DIM) which was accompanied by increased Nrf2 and NQO1 expression, the latter being a Nrf2-target gene. The gene discussed is NFE2L2; the disease is adenocarcinoma.