NDUFV1 and Parkinson disease: Specifically, mitochondrial activity is decreased in post-mortem brains of Parkinson’s disease (PD) patients [27–29], mutations in proteins controlling mitochondrial homeostasis causes early-onset PD [30, 31], and treating animals with the mitochondrial respiratory-chain complex I inhibitors rotenone or MPP+ recapitulates PD pathophysiology [32, 33].