SETD2 and mesothelioma: For example, in mesothelioma, KMT2B is also a driver of CIMP alongside SETD2. Therefore, in order to disentangle SETD2-specific changes, we conducted differential methylation analysis specifically comparing SETD2 WT and SETD2 mutated groups to remove the effect of confounders and reveal the SETD2-specific methylation changes.