EGFR and asthenia: The most common severe AEs (grade ≥ 3) documented in 10 of the 11 selected studies, including 1064 EGFR-mutated patients treated with EGFR-TKIs, were elevated alanine transaminase (11.9%, 95% CI, 0.0–32.3%), elevated aspartate transaminase (7.9%, 95% CI, 0.0–20.6%), rash (4.3%; 95% CI, 1.6–6.9%), stomatitis (1.8%, 95% CI, 0.4–3.2%), diarrhea (1.7%; 95% CI, 0.8–2.7%), pneumonia (1.2%, 95% CI, 0.2–2.1%), anorexia (0.7%, 95% CI, 0.0–1.4%), dry skin (0.4%, 95% CI, 0.0–0.9%), and asthenia (0.4%, 95% CI, 0.0–0.9%).