The findings in Table 3 highlight that in the following subgroups: subjects aged over 65 years, obesity, nonsmokers, individuals without diabetes and CHD, and those with higher levels of estradiol (≥ 6.22 pg/mL) and e-GFR (≥ 60 mL/min/1.73m2), the risk of hypertension were significantly lower in the higher quartiles of serum Klotho protein concentration when compared to participants in the first quartile. The gene discussed is KL; the disease is diabetes mellitus.