The findings in Table 3 highlight that in the following subgroups: subjects aged over 65 years, obesity, nonsmokers, individuals without diabetes and CHD, and those with higher levels of estradiol (≥ 6.22 pg/mL) and e-GFR (≥ 60 mL/min/1.73m2), the risk of hypertension were significantly lower in the higher quartiles of serum Klotho protein concentration when compared to participants in the first quartile. This evidence concerns the gene KL and obesity due to melanocortin 4 receptor deficiency.