A single intravenous administration of erenumab 140 mg in patients with stable angina did not aggravate exercice-induced angina or ST-segment depression [149], but this study was criticized because it explored a single acute administration too short before the treadmill test to allow for complete tissue distribution and comprised few women with angina in whom the distal coronary artery system, the most sensitive to CGRP, is chiefly involved. Here, CALCA is linked to angina pectoris.