Next, we tested the performance of clinical criteria relying on positive family history for HBOC (Manchester score), LS-associated cancer (Amsterdam II criteria, PREMM5 score), or PCa (Johns Hopkins criteria) in indentifying PCa patients with high probabilities for underlying PGVs in BRCA1/2 (n = 14) or DNA mismatch repair genes (n = 3). Here, BRCA1 is linked to cancer.