In addition, staining intensity in humanized hACE2 NIKO mice infected with WT and ∆382 virus as observed in histological stains of viral antigen (spike protein), human cell infiltration, human CD45+ lymphocytes and CD3+ T cells showed that humanized hACE2 NIKO mice can support WT and Δ382 infection (Fig. 4B). Here, PTPRC is linked to infection.