Since p53 is shown to be inactivated by TRIB1 in NSCLC and HCC, we next explored the interaction between TRIB1, p53 and COP1 in T08-387 cells that contain wild-type TP53. A co-immunoprecipitation of TRIB1 was performed, in T08-387-TRIB1-FLAG stable cells. The gene discussed is TRIB1; the disease is hepatocellular carcinoma.