These data were used to calculate etoposide IC50 values shown in Fig. 2A (right panel) for FaDu and additional cell lines, with values consistently lower for 1 μM AZD7648 + etoposide relative to the Top2 poison alone, indicating that DNA-PK inhibitors sensitize monolayer tumor cells to etoposide by at least a factor of 10. Here, PRKDC is linked to neoplasm.