Based on the progesterone resistance phenotype that we observed in the TRIM28 deficient HESCs under the hormone stimulation, it was not surprising that TRIM28 gene signature in the decidual HESCs also showed high resemblance with multiple human endometriosis datasets55–57, especially a positive correlation with multiple endometriosis subtypes including the Deep infiltrating endometriosis (DiE), OMA, and PP in comparison with the control endometrium (Fig. 9c, d). The gene discussed is TRIM28; the disease is endometriosis.