Hepatocyte-specific overexpression of CAND1 prevented the development of NAFLD by inhibiting the assembly of Cullin1, F-box only protein (FBXO42), and acetyl-CoA acyltransferase 2 (ACAA2) complexes and the subsequent ubiquitinated degradation of ACAA2. The gene discussed is ACAA2; the disease is metabolic dysfunction-associated steatotic liver disease.