For biomedical research, AuNPs has been shown to exhibit antiviral activity by some different mechanisms.27,28 For example, AuNPs were shown to bind to the glycoprotein spikes of herpes simplex virus type-1 (HSV-1) and block its interaction with cellular heparan sulfate proteoglycans (HSPGs), which are essential for viral infection.27 In our study, we used gold nanoparticles to interfere with organelle dynamics and organelle interactions, which resulted in the suppression of the virus. This evidence concerns the gene ART4 and viral infectious disease.