By constructing multiple Trim37 mutant mice (FINmajor, Trim37ko, Trim37cko, Trim37C18R/C18R, Trim37G322V/G322V), we found that respiratory tract infections and antibody deficiency in Mulibrey nanism patients could be ascribed to TRIM37-mediated regulation of protective antibody responses. The gene discussed is TRIM37; the disease is agammaglobulinemia.