Compared with the NC group, the blood biochemical indicators CK, Mb, BUN, and Scr of the CI group, as well as the results of HE staining and NGAL molecular immunohistochemistry staining of kidney tissue, showed that we also successfully constructed a mouse model of CS-AKI induced by CI (Fig. 7b, c, e–g). The gene discussed is LCN2; the disease is Cowden syndrome 1.