TNF and Cowden disease: 45 Its primary representative F. plautii [also known as E. plautii] is, with the other eubacteria, a well-recognized SCFA producer found in the healthy gut.46 Of note, its close relative, E. rectale, was reported to be significantly increased at baseline in children responding to anti-TNF in CD.39 A connection with CD has already been reported for the genus Intestinibacter47 from the family Peptostreptococcaceae; however, disease activity [remission vs active disease] and gut inflammation status was not considered.