CEMIP2 and neoplasm: Specifically, we showed that: (i) tamoxifen-induced global knockout of Tmem2 in adult mice leads to rapid and pronounced accumulation of uncleaved and partially cleaved HA in bodily fluids and a variety of organs (12); (ii) Wnt1-Cre–driven Tmem2 conditional knockout results in severe defects in neural crest derivatives, accompanied by aberrant HA accumulation in those tissues (13); and (iii) knockdown of TMEM2 in human tumor cells greatly impairs their ability to degrade HA in a contact-dependent manner (14).